Logo

Ionis Highlighted P-III Study (NEURO-TTRansform) Results of Eplontersen for the Treatment of THereditary Transthyretin-Mediated Amyloid Polyneuropathy

Share this
Ionis

Ionis Highlighted P-III Study (NEURO-TTRansform) Results of Eplontersen for the Treatment of THereditary Transthyretin-Mediated Amyloid Polyneuropathy

Shots:

  • The P-III study evaluating eplontersen in patients with ATTRv-PN at 35, 66, and 85wk. In the 66wk. primary analysis, eplontersen showed an improvement across all co-1EPs & 2EPs incl. serum transthyretin (TTR) concentration with LS mean reduction of 82% vs 11%
  • Improvement in neuropathy (47% vs 17%), and QoL (58% vs 20%), benefits on mNIS+7 and Norfolk QoL-DN at 35wks. further improved at 66wks. Eplontersen halted disease progression. The results were published in the JAMA
  • Improvements in all 2EPs through 66wks. and showed a favorable safety and tolerability profile, rate of TEAEs was comparable & no AEs led to study drug discontinuation. In the end-of-treatment analysis, eplontersen continued to sustain improvements through 85wks.

Ref: PR Newswire Image: Ionis

Related News:- Ionis Reports Two-Year P-II OLE Study Results of Donidalorsen for the Treatment of Hereditary Angioedema

PharmaShots! Your go-to media platform for customized news ranging for multiple indications. For more information connect with us at connect@pharmashots.com

Click here to­ read the full press release 

Senior Editor

Neha is a Senior Editor at PharmaShots. She is passionate and very enthusiastic about recent updates and developments in the life sciences and pharma industry. She covers Biopharma, MedTech, and Digital health segments along with different reports at PharmaShots. She can be contacted at connect@pharmashots.com.

Share this article on WhatsApp, LinkedIn and Twitter

Join the PharmaShots family of 12000+ subscribers

I accept the Terms and Conditions